Drug development is a lengthy process that costs the pharmaceutical industry hundreds of millions of euros. The ability to predict the potential success or failure of a candidate substance at a very early stage in drug development can offer significant time savings. Organs-on-a-chip can be used to improve and accelerate the development of new products.
On an organ-on-a-chip human cells (or stem cells) are cultured. In this way, the tissue properties and functions of various organs can be simulated. TNO focuses, in particular, on the organ functions of the liver, gut and lungs. These organs-on-a-chip will improve our ability to predict which drugs will work in whom. They will also improve our understanding of the variation between individuals, and show whether new products are safe. In addition, this technology will enable us to make a significant contribution to animal-free innovations.
Do you want to learn more about organ-on-a-chip? Download the whitepaper.
- Lecture series The Human Microbiome in Health and Diseasetno.nl
- Symposium “Organ on a chip: From dream to implementation”tno.nl
- Improving human PK predictions at AAPStno.nl
- Meet TNO at 5th Microbiome R&D and Business Collaboration Forumtno.nl
- Metabolite identification in Phase 1 via microtracer AMStno.nl
- Healthy Living